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Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome

Identifieur interne : 002071 ( Main/Exploration ); précédent : 002070; suivant : 002072

Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome

Auteurs : Scott D. Zawieja ; Olga Gasheva ; David C. Zawieja ; Mariappan Muthuchamy

Source :

RBID : PMC:4796620

Abstract

Flow-mediated inhibition of contraction frequency is blunted in metabolic syndrome (MetSyn) thoracic ducts (TDs) despite a comparable response to exogenous NO. While the NOS inhibitor l-NAME abolished this difference, the ROS scavenging molecule tempol did not restore flow responses in MetSyn TDs. A significant reduction in eNOS in Metsyn TDs is found.


Url:
DOI: 10.1152/ajpheart.00664.2015
PubMed: 26637560
PubMed Central: 4796620


Affiliations:


Links toward previous steps (curation, corpus...)


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   |texte=   Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome
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