Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome
Identifieur interne : 002071 ( Main/Exploration ); précédent : 002070; suivant : 002072Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome
Auteurs : Scott D. Zawieja ; Olga Gasheva ; David C. Zawieja ; Mariappan MuthuchamySource :
- American Journal of Physiology - Heart and Circulatory Physiology [ 0363-6135 ] ; 2015.
Abstract
Flow-mediated inhibition of contraction frequency is blunted in metabolic syndrome (MetSyn) thoracic ducts (TDs) despite a comparable response to exogenous NO. While the NOS inhibitor
Url:
DOI: 10.1152/ajpheart.00664.2015
PubMed: 26637560
PubMed Central: 4796620
Affiliations:
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Le document en format XML
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<series><title level="j">American Journal of Physiology - Heart and Circulatory Physiology</title>
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<front><div type="abstract" xml:lang="en"><p>Flow-mediated inhibition of contraction frequency is blunted in metabolic syndrome (MetSyn) thoracic ducts (TDs) despite a comparable response to exogenous NO. While the NOS inhibitor <sc>l</sc>
-NAME abolished this difference, the ROS scavenging molecule tempol did not restore flow responses in MetSyn TDs. A significant reduction in eNOS in Metsyn TDs is found.</p>
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<name sortKey="Zawieja, Scott D" sort="Zawieja, Scott D" uniqKey="Zawieja S" first="Scott D." last="Zawieja">Scott D. Zawieja</name>
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